Cordat Lab

Cordat Lab Page under construction These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance.

Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermato

genesis, vision, hearing or cardiovascular function. The Cordat’s lab has worked for many years on the kidney anion exchanger 1 (kAE1) protein. kAE1 mutations can be inherited and can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and renal calculi. We currently work on further understanding the function and regulation of kAE1 but also of other bicarbonate transporters from the SLC26A gene family.

Welcome to Mathieu Ruyssckaert and Celebration lunch for Grace's manuscript! The ramens were delicious on this freezing ...
03/05/2026

Welcome to Mathieu Ruyssckaert and Celebration lunch for Grace's manuscript! The ramens were delicious on this freezing day!

Here is our latest publication in eLife!https://elifesciences.org/articles/108253Congratulations to Grace for her hard w...
03/05/2026

Here is our latest publication in eLife!
https://elifesciences.org/articles/108253
Congratulations to Grace for her hard work on this project👏

Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.

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