Cordat Lab

Cordat Lab Page under construction These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance.

Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermato

genesis, vision, hearing or cardiovascular function. The Cordat’s lab has worked for many years on the kidney anion exchanger 1 (kAE1) protein. kAE1 mutations can be inherited and can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and renal calculi. We currently work on further understanding the function and regulation of kAE1 but also of other bicarbonate transporters from the SLC26A gene family.

Welcome to Mathieu Ruyssckaert and Celebration lunch for Grace's manuscript! The ramens were delicious on this freezing ...
03/05/2026

Welcome to Mathieu Ruyssckaert and Celebration lunch for Grace's manuscript! The ramens were delicious on this freezing day!

Here is our latest publication in eLife!https://elifesciences.org/articles/108253Congratulations to Grace for her hard w...
03/05/2026

Here is our latest publication in eLife!
https://elifesciences.org/articles/108253
Congratulations to Grace for her hard work on this project👏

Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.

Welcome to undergraduate research student Lynzae Ecaldre!
10/01/2025

Welcome to undergraduate research student Lynzae Ecaldre!

Here is our newest publication! Congratulations to first author Priyanka Mungara and all authors:
10/01/2025

Here is our newest publication! Congratulations to first author Priyanka Mungara and all authors:

Summary: Mouse lines carrying Ae1 L919X or R607H knock-in variations that mimic human distal renal tubular acidosis (dRTA) display urinary sodium waste, as seen in some patients with dRTA, and upregulation of tight junction proteins claudin 4 and 10b, when exposed to a salt-depleted acid challenge.

A pledge for a strong research in Canada leading to a future generation of leaders, and supporting innovation and prospe...
10/01/2025

A pledge for a strong research in Canada leading to a future generation of leaders, and supporting innovation and prosperity:

To fully leverage the capabilities of academic institutions, Canada must adopt a future-oriented research approach by aligning research priorities with national interests.

We are supporting an independent, non-partisan and world-class research in Canada!
03/18/2025

We are supporting an independent, non-partisan and world-class research in Canada!

Welcome to the CORE-COEUR : the Coalition for Research Excellence in Canada is an informal non-partisan coalition of researchers agreed that a robust research ecosystem is in the common interest and should be a strategic priority for the next Canadian Parliament and federal government. We are unitin...

Priyanka and Grace had a great time at the American Physiological Society Meeting in Long Beach California last week!
04/08/2024

Priyanka and Grace had a great time at the American Physiological Society Meeting in Long Beach California last week!

Congratulations to Dr. Shahid AKM Ullah for defending his Thesis! Well done Shahid!
07/12/2022

Congratulations to Dr. Shahid AKM Ullah for defending his Thesis! Well done Shahid!

Patio time with the lab!
07/12/2022

Patio time with the lab!

Check out our laboratory new website:
09/23/2021

Check out our laboratory new website:

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Room 734, MSB, University Of
Edmonton, AB
T6G2H7

Telephone

+17804920209

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Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermatogenesis, vision, hearing or cardiovascular function. The Cordat’s lab has worked for many years on the kidney anion exchanger 1 (kAE1) protein. kAE1 mutations can be inherited and can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and renal calculi. We currently work on further understanding the function and regulation of kAE1 but also of other bicarbonate transporters from the SLC26A gene family.